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Does Clopidogrel Interact With Celebrex?

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Posted on Thu, 21 Apr 2016
Question: I have osteoarthritis and have been taking celebrex for years. Love it and it is great. Last April I had an Ischemic(sp) stroke. I was put on Clopidogrel and continued to take Celebrex. I took it for 7 months and no Dr. noticed it until last month . the Dr. immediately took me off and my oa is back. It had no ill effects while I was still on it. So obviously it wasn't that bad.
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Answered by Dr. Ronald Schubert (10 minutes later)
Brief Answer:
Increased risk of heart attack and bleeding with celebrex

Detailed Answer:
Thank you for contacting HCM with your health care concerns

I am sorry to hear that you have had an increase in your pain since stopping Celebrex. Your doctor stopped the celebrex due to an increase in risk for heart attack and GI bleeding. Both of these conditions can be life threatening. Any anti-inflammatory may cause these adverse effects. So the tramadol was substituted for pain control. Unfortunatley it looks like the tramadol is not helping. I would recommend discussing your situation with your medical provider and see if they will restart the celebrex. I would not be too optimistic about that but it doesn't hurt to ask.

I hope I answered your question. Please contact us again if you have any additional questions
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Ronald Schubert

General & Family Physician

Practicing since :1984

Answered : 2407 Questions

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Does Clopidogrel Interact With Celebrex?

Brief Answer: Increased risk of heart attack and bleeding with celebrex Detailed Answer: Thank you for contacting HCM with your health care concerns I am sorry to hear that you have had an increase in your pain since stopping Celebrex. Your doctor stopped the celebrex due to an increase in risk for heart attack and GI bleeding. Both of these conditions can be life threatening. Any anti-inflammatory may cause these adverse effects. So the tramadol was substituted for pain control. Unfortunatley it looks like the tramadol is not helping. I would recommend discussing your situation with your medical provider and see if they will restart the celebrex. I would not be too optimistic about that but it doesn't hurt to ask. I hope I answered your question. Please contact us again if you have any additional questions