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Does Ciprofloxacin Interact With Venlafaxine, Ranitidine, Amitriptyline And Bisoprolol?

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Posted on Sat, 2 Apr 2016
Question: I have made an error by taking:

2 x Ciprofloxacin 250mg tablets instead of 1
Naproxen 500 mg 1 tablet
Co-Codamol 30/500 2 tablets

Are these tablets OK to take together and do I need to stop taking any other medications today that I normally take

I normally take:

Venlafaxine 150mg a day
Ramapril 5mg a day
Bisoprolol 2.5 mg a day
Amitriptyline 20mg a day
Metformin 500mg a day
Ranitidine 300 mg a day
Simbastatin 10mg a day
Lansoprozole 30 mg a day

doctor
Answered by Dr. Michelle Gibson James (1 hour later)
Brief Answer:
most serious potential interaction is between venlafaxine and amitriptyline

Detailed Answer:
HI, thanks for using healthcare magic


There are some infections that require ciprofloxacin 500mg so the fact that you took two of the 250mg tablets( 500mg) is ok in terms of the dose itself.

In terms of drug interactions, the most serious potential interaction is between 2 of the drugs that you normally use-venlafaxine and amitriptyline

They both increase the levels of a chemical called serotonin causing serotonin syndrome, high likelihood of serious reaction. Generally the combination is not advised unless the benefit outweigh the risk.

Ciprofloxacin can potentially increase the effects of metformin but this is not likely to have a significant effect.
Naproxen can decrease the effect of bisoprolol so the blood pressure should be monitored though this effect may not be significant, it also decreases the effect of ramipril.

Venlafaxine and naproxen can potentially act to increase the toxicity (side effects) of each other, this may or may not occur.

There are possible interactions but if you are using the antibiotic and the pain killer for a short period of time it is likely that no serious problems would occur.

The more serious potential interaction is between venlafaxine and amitriptyline but if you have been using these for a long time with no problems then it may possibly be continued if the benefits outweigh any problems

I hope this helps, feel free to ask any other questions
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
Dr.
Dr. Michelle Gibson James

General & Family Physician

Practicing since :2001

Answered : 16808 Questions

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Does Ciprofloxacin Interact With Venlafaxine, Ranitidine, Amitriptyline And Bisoprolol?

Brief Answer: most serious potential interaction is between venlafaxine and amitriptyline Detailed Answer: HI, thanks for using healthcare magic There are some infections that require ciprofloxacin 500mg so the fact that you took two of the 250mg tablets( 500mg) is ok in terms of the dose itself. In terms of drug interactions, the most serious potential interaction is between 2 of the drugs that you normally use-venlafaxine and amitriptyline They both increase the levels of a chemical called serotonin causing serotonin syndrome, high likelihood of serious reaction. Generally the combination is not advised unless the benefit outweigh the risk. Ciprofloxacin can potentially increase the effects of metformin but this is not likely to have a significant effect. Naproxen can decrease the effect of bisoprolol so the blood pressure should be monitored though this effect may not be significant, it also decreases the effect of ramipril. Venlafaxine and naproxen can potentially act to increase the toxicity (side effects) of each other, this may or may not occur. There are possible interactions but if you are using the antibiotic and the pain killer for a short period of time it is likely that no serious problems would occur. The more serious potential interaction is between venlafaxine and amitriptyline but if you have been using these for a long time with no problems then it may possibly be continued if the benefits outweigh any problems I hope this helps, feel free to ask any other questions