I have been taking brintellix 5mg. with Cymbalta 60mg and amberon 7.5 mg. for 10 days now. The last 3 days I have been experiencing hoarseness. I also take opiods for severe osteoarthiritis pain, .5mg Xanax 3 times daily, flexeril - 2 times daily, halcion - .25 nightly, amberon 7.5 nightly. The brintellix is new for me. I have been on the other meds for years. Also concerta 18mg. daily. I am afraid that the hoarseness has something to do with serotonin syndrome! Since I started taking it, I actually feel human for the first time in 37 years of trying tons of other antidepressants. I m not manic, I just feel like a real person. But I am terrified of the serotonin syndrome. Should I ask my doctor to cut out the other antidepressants and just take the brintellix, and could the hoarseness be associated with this new drug? I have never felt as leveled out as I do now, and I want desparately for this to be the drug that finally helps me with my major depressive disorder, but am very concerned about the serotonin syndrome!! Please help!!