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Can Escitalopram And Hydroxyzine Be Taken Together?

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Posted on Tue, 20 Dec 2016
Question: I was given 10 mg of escitalopram to be taken daily for anxiety and 25 mg of hydroxyzine hcl when needed during an anxiety attack. But i read that there are interactions between the two and they shouldn't be taken together. So i was concerned about whether it was safe to take the hydroxyzine if needed?
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Answered by Dr. Bonnie Berger-Durnbaugh (56 minutes later)
Brief Answer:
Information

Detailed Answer:
Hello,

The combination of escitalopram and hydroxyzine can cause for some people, a heart rhythm problem, and so the combination is considered to be a risk for major interaction. However this problem is considered relatively rare, but still it is a consideration.

Using hydroxyzine is not usually a first choice medication for acute panic attacks. Most physicians prescribe one of the shorter acting benzodiazepines such as lorazepam for occasional attacks. It's effects are much more specific for addressing panic and anxiety and it's onset of action is fairly quick. Hydroxyzine is a 1st generation antihistamine and it's effects that might be beneficial to a panic attack would be that it has the side effect of sedation. But it is not specifically an anti-anxiety medicine as lorazepam is.

The reason your doctor may have chosen hydroxyzine instead is that the benzodiazepines can be dependency forming if you take them every day. But for occasional use (a few times per week) they are not.

Benzodiazepines such as lorazepam and alprazolam are compatible with escitalopram.

I recommend talking with your doctor about this option.
Note: For further follow up on related General & Family Physician Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Bonnie Berger-Durnbaugh

General & Family Physician

Practicing since :1991

Answered : 3134 Questions

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Can Escitalopram And Hydroxyzine Be Taken Together?

Brief Answer: Information Detailed Answer: Hello, The combination of escitalopram and hydroxyzine can cause for some people, a heart rhythm problem, and so the combination is considered to be a risk for major interaction. However this problem is considered relatively rare, but still it is a consideration. Using hydroxyzine is not usually a first choice medication for acute panic attacks. Most physicians prescribe one of the shorter acting benzodiazepines such as lorazepam for occasional attacks. It's effects are much more specific for addressing panic and anxiety and it's onset of action is fairly quick. Hydroxyzine is a 1st generation antihistamine and it's effects that might be beneficial to a panic attack would be that it has the side effect of sedation. But it is not specifically an anti-anxiety medicine as lorazepam is. The reason your doctor may have chosen hydroxyzine instead is that the benzodiazepines can be dependency forming if you take them every day. But for occasional use (a few times per week) they are not. Benzodiazepines such as lorazepam and alprazolam are compatible with escitalopram. I recommend talking with your doctor about this option.