Hello, Brief Answer: Yes, sometimes antidepressants can cause shakes and a heavy stomach. Detailed Answer: First of all, it would have been better than you have told the name of antidepressants you take. •     Some side effects of antidepressants are: feeling agitated, shaky or anxious •     feeling and being sick •     indigestion and stomach aches •     diarrhea or constipation •     loss of appetite •     dizziness •     not sleeping well (insomnia), or feeling very sleepy •     headaches •     low sex drive •     difficulties achieving orgasm during sex or masturbation •     in men, difficulties obtaining or maintaining an erection (erectile dysfunction) •     confusion •     agitation •     muscle twitching •     sweating •     shivering •     diarrhea •     feeling listless and tired •     disorientation •     agitation •     psychosis •     seizures (fits) etc Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Enton Dore, General & Family Physician