i have routine blood work done yearly and last month my GFR came back 59, HCT 31, nml w/ cr 1.0. i have markers for sjogrens, not clinical diagnosis, chol 203, hdl 54, ldl 110 triglycerides 88 and BP is 110/70 s ballpark average, microprotein 44 in urine from 4 last sept. i have no other healthproblems. repeat GFR 58, HCT 37 bun/cr same, chol level same but CO2 20, and microprotein is down to 8 in urine (cut protein down to minimum..i was big protein eater). i am worried about GFR. only thing i can think of that could have caused this is taking ibuprofen/benadryl during a 3 week period when i broke my rib prior to having labs drawn..and i took the ibuprofen regularly. i drink lots of water always. also since feb, i have increased exercise phenomenally. is it possible to turn this GFR around? and how quick does kidney failure take? am i on a downward spiral? i have next appt w/ Primary doc in 1 month, am repeating labs til then. what can i do that i am not doing to retard/repair circumstances? is it permanent damage?..