Hallow Dear, Gestone is a progesterone preparation. Further more you are using lutinus vaginal pessaries also, which again are progesterone. Progesterone is smooth muscle relaxant and thus relaxes even the blood vessels. Therefore drop in blood pressure after progesterone injection (and vaginal pessaries in addition) is a known side effect. It is most likely that your blood pressure is getting lowered which causes hot flushes and sweating at night. Please take your Gynaecologist s opinion. If it is not alarming, please continue taking Gestone and lutinus since Progesterone helps to stabilize the pregnancy. Since you are on ICSI treatment, doctors are taking all the precautions to support your pregnancy and minimize the chances of any abortion. Your previous pregnancies were not supported by Gestone and they unfortunately ended in abortion. Therefore, this time the doctors have taken additional preventive precaution by giving Gestone to prevent the possibility of abortion. I hope Gestone and lutinus will work to stabilize your pregnancy and you will have a bonny baby to breastfeed at the end of the term. Dr. Nishikant Shrotri