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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes High AST And ALT Level?

Hi i m 29yr old Male 100kg 5.7ft, few days back i started to having dark yellow urine, i started to worry i got my LFT checked following were the result bilirubin 0.8mg/dl ALT 110 AST 61 and ALP 253 and also checked for HEP A,B,C all were negative i m not a drinker but i do smoke. i also checked with the doctor he done ultrasound check on my liver, kidney, pancreas all were fine with no problem, i am still worried why is my ALT and AST level high. For the past 2 year i was talking orlistat for weight management than my alt was around 50-70 but when i stopped last month due to FDA warning that it may cause liver failure. Than my alt level came to normal level after discounting orlistat but now my alt is much higher when i was taking orlistat. could u suggest what could be the reason and what other test should i take. i also took test for UTI which was also clear. Thanks
Tue, 24 May 2016
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Gastroenterologist 's  Response
Thank you for posting query.

increase in the level of liver enzymes(AST,ALT) reflect an INJURY to the Liver. medically, the condition is know as "Hepatitis". It maybe caused by viral infection, alcohol, certain drugs, autoimmune diseases, gall stones, increased iron, increased copper, increased fat in body. as most of your test negative, kindly get following done also:
1. serum iron and ferritin level
2. serum copper 3. autoimmune profile (ANA, anti dsDNA)

advice:
abstinence from "Alcohol and drugs"
- LOW fat diet should be followed
- NO red meat
- vegetables should be ingested daily
- Moreover, less activity should be carried out (no sports).
- use lemon juice (lemonade) once in a day
- walk 30 to 40 minutes everyday.
- or swimming is alternative to walking
- NO sports and NO jogging
-"recheck liver enzymes after 6 to 8 weeks".

if any further questions, feel free to ask.

Health professionals aim to diagnose properly and manage patients according to their limited knowledge. Cure is blessed by the ONE who Created us, whose power and knowledge is unlimited .
wish you good health.
regards,
Dr Tayyab Malik
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What Causes High AST And ALT Level?

Thank you for posting query. increase in the level of liver enzymes(AST,ALT) reflect an INJURY to the Liver. medically, the condition is know as Hepatitis . It maybe caused by viral infection, alcohol, certain drugs, autoimmune diseases, gall stones, increased iron, increased copper, increased fat in body. as most of your test negative, kindly get following done also: 1. serum iron and ferritin level 2. serum copper 3. autoimmune profile (ANA, anti dsDNA) advice: abstinence from Alcohol and drugs - LOW fat diet should be followed - NO red meat - vegetables should be ingested daily - Moreover, less activity should be carried out (no sports). - use lemon juice (lemonade) once in a day - walk 30 to 40 minutes everyday. - or swimming is alternative to walking - NO sports and NO jogging - recheck liver enzymes after 6 to 8 weeks . if any further questions, feel free to ask. Health professionals aim to diagnose properly and manage patients according to their limited knowledge. Cure is blessed by the ONE who Created us, whose power and knowledge is unlimited . wish you good health. regards, Dr Tayyab Malik