Hello, and I hope I can help you today. Oral progesterone has no role in the management of pregnancy after the first trimester. You do not need to worry at this point that it has actually hurt the baby, as progesterone is produced in normal healthy pregnancies. In your case, your history of a cystectomy and your low-lying placenta (which likely will go away by the third trimester) are are not actual risk factors for any obstetric complications. So I do not believe that you need to continue the progesterone therapy. There is no harm to the pregnancy that could have come from taking it in the first place, as injectable and suppository forms of the drug are used to treat women at high risk for preterm delivery. So in summary, as long as you have no further complications of your ovaries, and your low-lying placenta resolves by term, there is no reason that you may not have a normal vaginal delivery. I hope I was adequately able to answer your question today, and that my advice was helpful. Best wishes for the rest of the pregnancy, Dr. Brown