Hi, I can understand your concern regarding PCOS and whether you will be able to ovulate and become pregnant. Let me assure you that there is no reason why it will not happen. Healthy choices aren’t just common sense when you have PCOS. Eating wisely, being physically active, sleeping well, and managing your stress can help reverse the hormone imbalances at the center of polycystic ovary syndrome and the symptoms those hormone changes cause. Research shows over and over again that managing your weight, even shedding a small percentage of your excess pounds and exercising regularly can improve symptoms such as irregular periods and infertility, and improve the effectiveness of medications used to help manage your glucose and improve insulin resistance in polycystic ovary syndrome (PCOS). So, yes, Sysron which is a synthetic form of progestin and has a similar action to the female hormone, progesterone will certainly help if taken concurrently with Metformin which will take care of your glucose metabolism. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Prabhash Verma, General & Family Physician