Insulin resistance

What is Insulin resistance?

Diminished effectiveness of insulin in lowering plasma glucose levels, arbitrarily defined as a daily requirement of at least 200 units of insulin to prevent hyperglycemia or ketosis; usually due to binding of insulin or insulin receptor sites by antibodies; associated with obesity, ketoacidosis, and infection.

Questions and answers on "Insulin resistance"

hi ,iam 45 yrs old woman 1.72height and 100kg weight .i use low fat foods and don,t eat rice and bread but i am fatter than yesterday .i have a larg belt size and my serum TG is 450 .am i a insulin resistance ? and what must i do for be thinner and slimmer?

doctor1 MD

do not worry about triglyceride,
take plenty of water,fresh fruits,high fiber diet ,leafy veg,soya products.
avoid alcohol,smoking,cola,coffee,junk foods.
do swimming,cycling,
think positive,
take sound sleep.
get blood test for lipid profile,sugar,thyroid profile.
consult physician for medicines...

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Hi ,do you think that if I have been treated couple years ago for hypothyroidsm and early hashimoto`s dissease,(but I am not taking any pills anymore)becouse doctor said my blood work is fine. and now I have to take metformin for insulin resistance, that this can has something to do with thyroid?

doctor1 MD

Hello and thank you for asking!
Insulin is a hormone made by your pancreas. It allows your cells to use glucose (sugar) for energy.
People with insulin resistance have cells that don’t use insulin effectively
It’s not entirely clear why some people develop insulin resistance and others don’t....

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I have recently detected with PCOD, and she has prescribed me tablet Gluconorm R (500mg)
I wanted to check if this is fine for me.
I am 30 year female , married 5 months back, planning pregrency and my current weight is 79KG.

doctor1 MD

Hi,
Thanks for the query.

Poly cystic ovary disease is characterized by menstrual irregularities like delayed or absence of periods, anovulation and insulin resistance etc.
Metformin is a insulin sensitizer and helps in treating the insulin resistance of the PCOD.
By this it also helps in...

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my bp is 150/100 and my triglyceride was 290. so since i have a family history of diabetes and heart diseases my doctor made me undergo a few tests and it was found my insulin resistance is about 200 or so and so he prescribed rozavel f and ecosporin 75 as a precaution. so what is your opinion regarding this

doctor1 MD

Dear sir i can understand your concern.in my opinion there are many issues un answerd in your case.
1.you find about your diabetes basic test like fating blood sugar and Hba1c was not done why?
2.i guess its not necessary to calculate insulin resistance in individuals with out going for simple...

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Hi,

I believe I have insulin resistance/carbohydrate sensitivity as I cannot maintain weightloss unless I stay below 50 grams of carbohydrate per day. Also, despite my blood work showing great insulin/blood sugar levels (likely due to my extremely low intake of carbohydrates regularly) my 2 hr post prandial is always higher than my 1 hr. I am not overweight but struggle greatly to maintain. Have hypothyroid, with family history of diabetes and thyroid illnesses. My dr doesn't believe in insulin resistance. What should I do?

doctor1 MD

HI, thanks for using healthcare magic

Insulin resistance is a possible cause for difficulty losing or maintaining weight loss.

The ratio of triglycerides to HDL cholesterol is sometimes used to determine if a person is likely to be insulin resistant. If your triglycerides/HDL is greater than 3.5...

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What is the effect of gucagon? Does it make glucogenesis happen and helps the liver synthesize urea? Is it true that human growth hormone stimulates triglyceride lipolysi in fat cells, milk synthesis by lactating mammary glands, and menarche, but does not produce insulin resistance?

doctor1 MD

Hello XXXXXXX

Thank you for posting on Healthcaremagic.

I will try to to answer you queries one by one.

What is the effect of glucagon?
Glucagon is a hormone released by alpha cells in the pancreas (Insulin is produced by beta cells). Glucagon functions exactly opposite to Insulin. Glucagon acts...

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Hi. I was rediagnosed last July with Insulin Resistance, I've been frightened, frustrated and quite alone with this and I really need advice. I've just had my third glucose tolerance test yesterday morning and I was shocked to see how dramatic the figures have become:

Fasting level - 6.3
plus 1/2 hour - 15.2
plus 1/2 hour 17.1
plus 1/2 hour - 15.4
plus 1/2 hour - 5.4

I am still feeling sick and weak after it. On the last test (my second one) the final level was 2.4 and I was also diagnosed as having reactive hypoglycaemia. I am very concerned about the levels from yesterday but my next appointment with my endocrinologist isn't scheduled until October although the phlebotomist said that she would probably call me on receipt of them. But in the meantime and because I'm worried, could you tell me if this looks like a diabetic pattern? I'm doing everything I can in terms of diet to control blood glucose levels and I’m, only 9st 1/2lb (I'm 5'7.5") and lost a further 4lbs without trying this last month. I'm feeling fairly desperate about this as I can't seem to control anything.

Just to say I'm taking 2500g metformin per day. It was 2 tablets after breakfast, 1 after lunch and two after dinner but my doc changed it last week as my highest levels of the day were occurring in the morning so she changed it to 3 tablets after breakfast, 1 after lunch and 1 after dinner.

What is really bothering me is that I can't seem to control the rise and fall of the blood glucose. This wave pattern, I know, is characteristic of Insulin Resistance but even with strictly controlling my diet and metformin and exercise, it has just started going crazy. My eye sight has worsened in the past few months. I am constantly tired, my head won't work, I have no concentration, am prone to terrible short term forgetfulness and if I try to exert myself even around the home, its as if a plug has been pulled, all power leaves me and my blood sugar levels drop like a stone.

There is though a pattern within the absence of pattern in that my blood sugar will rise at the drop of a hat in the morning while I can withstand challenges (in the form of food!) later in the day particularly the evening. To give an example - this morning I ate 2 tbls yogurt, 1 dsp chopped nuts and half a grated XXXXXXX mixed together with a half slice wholemeal toast and a cup of coffee. Before breakfast my level was 5.7 but afterwards it XXXXXXX (half an hour later) to 11.4. Curiously, I had chicken stirfry (my own!) last night for dinner. My level before was 6.1 but after my much larger meal it XXXXXXX only to 7.8!


Is this now diabetes?
XXXXXXX

doctor1 MD

The endocrinologist you saw has given you sound advice. Do not try to fully understand how hormones work because even we do not know exactly everything about hormones. They are complex chemical substances in the body that do several things, some of which we physicians and scientists understand...

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hi doctor...am now in my sixth monthy of pregnancy..i am taking tablet for thyroid,metformin for insulin resistance and all other vitamine tablets like iron and calcium. nowadays i am having vomiting and fainting.. not daily..i did my 22nd week scan and everything was normal..blood pressure ws also normal.now i am having little emotional stress..

doctor1 MD

Hello dear,
I understand your concern.

Iam happy to know that your BP is normal.

In my opinion the vomitings might be due to gastritis.

Avoid spicy and oily diet.
Take antacids and antiemetics.

Check for any fever associated with vomitings.

If fever is there along with vomitings then the cause of...

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HI, I HAVE SMALL CYSTS ON LEFT OVARY ,AN IM TAKING DIMET 850 MG DAILY,BUT IM FEELING BREATHING PROBLEM SO CAN I STOP TAKING IT?IS THERE ANY ALTERNATIVE ,PLEASE SUGGEST THANKS

doctor1 MD

Hi, thanks for asking in Healthcare Magic,

GMET 850 or Metformin is given in Poly Cystic Ovarian Disease (PCOD). In PCOD there is insulin resistance. Insulin increases the utilization of glucose by peripheral tissues. Lack of insulin action results in increase in blood sugar levels (Diabetes)....

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Recent questions on  Insulin resistance

doctor1 MD

hi, i had insulin resistance but through diet and exercise have taken 20cm off my belly and no longer have it. i have a full medical every year and everything seems to be functioning fine but no one can tell me why my stools are so smelly. it is to a point where i will not go at work because it is so embarrassing. Why could this be? :(

doctor1 MD

hello. i am a 24 yr old female. i have asthma. For the past 6 years i experiance bouts of extreme fatigue, swollen chin and auxillary nodes, diarrhea, muscle pain and weakness, small headaches, gerd, and my skin is always tender to the touch to the point were hugs are painful and also something as small as snapping my fingers hurts. It also seem sthat my tolerance for pain has greatly diminished. Also, i have no to low sex drive and my mentral cycles have always been irregular, ocurring from 2-3 months, where now i have gone 6 months without one, occuring. I have had a million blood tests at the doctors and he can never seem to find anything physically wrong with me other than insulin resistance. I was reading about cfs/ fibro and wondering if this sounds like what it could be. Medical history: Asthma 20 yrs.(i have been intubated twice due to asthma attacks) Insulin Resistance. I had a diagnosis of ebv in 2004. I currently take albuterol inhaler and prednisone on and off as needed for about a weeks time for the past 15 yrs.

doctor1 MD

Hi, I am taking Duromine 40mg, and my urine is quite dark and odorous all day. I am drinking about 2 litres of water per day. I am not diabetic, but I took my BSL yesterday about 5hrs after lunch and it was 6.9. Is this a side effect, or should I investigate further - maybe insulin resistance? (had BSL done about a year ago and was perfect according to GP) thanks

doctor1 MD

I am 66, 5'2" and 155lbs. I developed a fib 2 years ago (now regulated) and was put on an older beta blocker plus I have high blood pressure for which I am now on the 5th different med ...I take 0.137 mg synthroid daily for 30 years, strength has varied over the years from 0.075 to as high as 0.2mg...my tsh, which is the only measurement my physician will consider, is usually 2.5 or thereabouts...in the last few months my hypothyroid symptoms have increased and on the last lab my tsh was very high, over 8 so I know my thyroid level is very low...I am very fatigued, depressed and most upsetting am eating less and getting fatter, where before I was overweight but firm and now I can feel fat in my thighs and upper arms plus around my abdomin which I never had before. Research shows the older type of beta blocker, atenolol, can slow metabolism and cause insulin resistance, (I am not diabetic) is it safe to simply stop one beta blocker and start another...in fact, I'd like to get off it altogether but the last time my physician said to just stop taking it, I developed pvc's which was corrected by increasing the atenolol. I am distressed about the side effects of this drug and wld like to take something less toxic.

doctor1 MD

Dear Dr. Ditah, THANK YOU for asking me how I am doing, as I do have several follow questions for you Here goes: 1. I have believed for some time now that I have some form of inflammation or infection in the area of my eye cage and forehead. This...

doctor1 MD

she is 3.4 years as of now, she developed some power in left eye. thus we had doubt if she develop Type 2 diabetes , when checked today post lunch her sugar level was 155. Her mother having type 2 diabetes since 5 years and taking insulin , even...

doctor1 MD

hi I'm a 23 yr old female being treated for pcos . I'm taking prescribed metformin (2000mg/day) I'm currently trying to get pregnant and was wondering if a doc could look at my chart and tell me if I possibly ovulated. this is my first month...