Hello Since your husband is just 21 years old and developed M D R TB . But don t desperate your husband will be alright . I am prescribing a full treatment .Be careful that don t stop this treatment before 30 months time . If any MEDICINE don t adjust at once inform . Since your husband is just 21 years so I am giving complete detail. MDR bacilli & MDR tuberculosis :MDR bacilli are resistant to at least ISONIAZIDE & RIFAMPICIN, the main anti tubercular drugs. MDR is the most severe form of bacterial resistance today. 1 Streptomycin 15 mg / kg body weight for 3 months I M injection , painful but apply heparin locally with ice sponging. OR KANAMYCIN OR AMIKACIN 2 Ehionamide 10-20 mg / kg body weight . 3 Pyrazinamide 20-30 mg / kg body weight . 4 Levofloxacin 10-15 mg / kg body weight once in day. 5 Ethmbutol 15-20 mg / body weight 6 Cycloserine 10-20 mg / kg body weight . Usually few doctor advise PAS also but I don t like. Now how I adjust these drugs to my patient . 1 Injection streptomycin 1 gm ( weight wise) I M / day , but if patient feel any dizziness or vertigo . Stop at once. 2 Tablet ehionamide + cycloserine 250 mg+ pyrazinamide 750 mg, each twice in a day ( morning & evening ) with pantaloc-d . 3 Levofloxacin 750 mg in the night after meal with clonazepam 0.25 mg for first 10-15 day and thereafter on alternate day only clonazepam . Levofloxacin continue till 30 months. 4 Tablet ethmbutol 800 mg once in day at 12 noon once in day for 3 months . If your husband is having breathlessness ( asthma ) then add monteleukast+ bambuterol , once in the night. Add antacid + high protein diet like cheese ,milk . Although patient will feel nausea and vomiting many times but ondansetrone will help. I also advise Ringer lactate IV drip + cynacobalamine 2ml ( 3-4 amp in each bottle ) on alternate day for 10 day means 5 bottles in all. Before I V drip lung capacity ( pulmonary function test ) should be checked. Hope this will help you . Good luck for your husband.