Shingles is characterized by a painful skin rash with blisters. It is caused by varicella zoster virus. Chickenpox is due to an initial infection with VZV. Once chickenpox has resolved, the virus may remain inactive in nerve cells. Shingles occurs when viral antibody titer and cellular immunity decline to levels that allow viral reactivation. Predisposing factors are old age, immune-compromised patients such as HIV infection, patients on chronic steroid and chemotherapy. Shingles resolves within 3–5 weeks, but secondary bacterial infection and chronic pain due to post – herpetic neuralgia may occur. Vaccination reduces the frequency of post – herpetic neuralgia. Advice 1. Take Zostavax vaccine if you are more than 50 years under medical supervision 2. For fresh attack, you can take valaciclovir 500 mg three times daily per oral if blisters are covering large area. No need of oral valaciclovir if blisters are localized to smaller area 3. Apply locally aciclovir 3% ointment five time daily 4. Do not take mental stress as it aggravates shingles For post – herpetic neuralgia 1. Gabapentin 100 mg three times daily for 10 days 2. Methylcobalamin 500 mcg once daily per oral for 3 months Thanks