Hello, Thank you for the question and welcome to Healthcaremagic! In order to help you out accurately i will some more information about you wife like what is her age? since how many days is she having fever? Any other complaints apart from fever and soar throat like cough dry or wet/ burning urination/ any rash or boils on body/ abdominal pain? If she does not have any other complaints apart from soar throat and fever of less than 7 days duration then its likely to be due to pharyngitis which is throat infection. Most throat infection are viral and resolve on their own without need of antibiotics. However if she also has cough/ neck node swelling ,the cause will be bacterial and she will need simple antibiotics like amoxicillin or azithromycin tablet for course of 5 days. Contact your local physician for examination to find if she needs antibiotic. In addition to this for reducing the fever, paracetamol tablet needs to be given one tablet 2 times a day at 8 hrs gap and maximum upto 3 times a day if the fever comes in between. To reduce the fever paracetamol works better than ibuprofen. However if the fever is more than 5-7 days duration, has additional symptoms as described above, she will need antibiotic course to help her resolve the infection.Contact your local physician for prescription. Hope this cleared your doubt. Contact back for any further questions. Takecare!