hello sir thanks for the query CKD chronic kidney disease complication of diabetes..the bitter act of diabetes is dat a doctor can only delay the onset of complications and delay its progression but can never prevent frm complications occuring.. in ur case metformin is nt ptrescribed if creatinine is more than 2.5 and u r losartan will take care of progression of complications...but once u r diagnosed as CKD a detail work up is required as to asses when u require dialysis and any plans for transplant...anf to evaluate other diabetic complications Thank you