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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Should I Be Worried About Increased Dosage Of Warfarin For Lung Embolism When My INR Keeps Dropping?

I'm female 55, 5'5" 297 lbs (And dropping...from 374) On warfarin for a lung embolism, but my INR keeps dropping. I have no idea why. Today it was 1.3. I don't eat dark green veggies, I do have a salad made with iceberg lettuce about 4X's a week and 2/3 cup coleslaw maybe once a week. (It's how I'm losing weight) My nurse hiked my dose up to 7.5 today...should I be worried?
Fri, 7 Feb 2014
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Internal Medicine Specialist,  's  Response
hi,
you are on high dose, yet poorly controlled INR.
Warfarin is one of the drugs whose metabolism is dependent on many factors.
This is a commonly encountered problem with warfarin. we handle these situations by replacing warfarin with other coumarin derivatives (eg; nicoumalone etc) which may help in some individuals. you may discuss with your doctor and ask for a change from warfarin to other anticoagulants, which can bring back your INR to target range (INR>2.5 is required for you.) Hope this helped.
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Should I Be Worried About Increased Dosage Of Warfarin For Lung Embolism When My INR Keeps Dropping?

hi, you are on high dose, yet poorly controlled INR. Warfarin is one of the drugs whose metabolism is dependent on many factors. This is a commonly encountered problem with warfarin. we handle these situations by replacing warfarin with other coumarin derivatives (eg; nicoumalone etc) which may help in some individuals. you may discuss with your doctor and ask for a change from warfarin to other anticoagulants, which can bring back your INR to target range (INR 2.5 is required for you.) Hope this helped.