Thanks for writing your query to healthcaremagic. Twynsta is combination of Telmisartan + Amlodepin. Both are antihypertensive. Micardis contains only Telmisartan. Since your blood pressure is not under good control with 1 medicine alone so your doctor has changed your prescription to Twynsta which is combination of two medicines. You can continue to take this medicine. Its right that medicines have side effect , but every patient reacts to same drug in different manner. Some one else had side effect that does not mean you will also have the same problems. For you it is more important that you keep your blood pressure in control so kindly continue with this medicine & regularly monitor your blood pressure with your physician. I hope i have answered your query. In case of any further doubts, I will be happy to help you.