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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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On Fertility Treatment. Suffer From PCOS. Not Able To Conceive. On Metformin. Success Rate Of IUI?

hello doctor.
am suffering from pcos and i am on fertility treatment.
i underwent 4 cycles of clomid with no success in conception.. I am asked to undergo iui.. am on metformin 850mg twice a day.
my period cycle average is 33 to 35 days..
please tell me the success and benefits of iui and will i be successful with this procedure?
Tue, 28 May 2013
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  User's Response
Welcome to HCM! Pregnancy in PCOS (polycystic ovary syndrome) is difficult because of lack of ovulation. If induction of OVULATION has failed with clomid (CLOMIFENE CITRATE) which acts by increased production of GONADOTROPHINS; it is unlikely that it will succeed with METFORMIN which is principally an anti-diabetic drug.
Are you obese? - Life-style modification to reduce CENTRAL OBESITY may resume ovulation and normal/ regular menstrual cycles; a low GI (glycaemic index or sugar) diet consisting of carbohydrates obtained from fruits, vegetables and whole grain cereals, vitamin D supplementation and regular exercise like brisk walking for 30 minutes a day may lower INSULIN LEVELS and reverse PCOS.
The success of IUI (intra-uterine insemination) is 10-15% in a single ovulatory cycle and 60-70% of six such cycles; optimum chances if you are less than 30 years old and TMS (total motile sperms) in donor male is more than 5 million per ml; most likely conception if there are 2 follicles of more than 16 mm and oestrogen of more than 500 pico gm/ ml on the day of hCG administration.
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On Fertility Treatment. Suffer From PCOS. Not Able To Conceive. On Metformin. Success Rate Of IUI?

Welcome to HCM! Pregnancy in PCOS (polycystic ovary syndrome) is difficult because of lack of ovulation. If induction of OVULATION has failed with clomid (CLOMIFENE CITRATE) which acts by increased production of GONADOTROPHINS; it is unlikely that it will succeed with METFORMIN which is principally an anti-diabetic drug. Are you obese? - Life-style modification to reduce CENTRAL OBESITY may resume ovulation and normal/ regular menstrual cycles; a low GI (glycaemic index or sugar) diet consisting of carbohydrates obtained from fruits, vegetables and whole grain cereals, vitamin D supplementation and regular exercise like brisk walking for 30 minutes a day may lower INSULIN LEVELS and reverse PCOS. The success of IUI (intra-uterine insemination) is 10-15% in a single ovulatory cycle and 60-70% of six such cycles; optimum chances if you are less than 30 years old and TMS (total motile sperms) in donor male is more than 5 million per ml; most likely conception if there are 2 follicles of more than 16 mm and oestrogen of more than 500 pico gm/ ml on the day of hCG administration.