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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Liver Transplant Done. Liver Enzyme Test Shows Elevated SGOT, SGPT. How To Reduce Levels?

hi, my mom got liver transplant 3 months already and she needs to test her blood once a few weeks and it seems that her SGOT SGPT have been increasing, now are about 200 something both of them. What could be reasons and how to reduce them? Doctor told that other value after tested are fine, so it seems that he only waits and sees results, but i m not sure what he s thinking to do with this.
Sat, 3 Nov 2012
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Internal Medicine Specialist 's  Response
Hi,
Liver enzymes after a liver transplant is more complex. First of all it would be important to know if your mother was infected with Hepatitis C prior to transplant, as the virus comes back 100% of the time with a new liver, therefore it can cause liver enzyme elevation. The fact that she is 3 months post-transplant makes someone think also about organ rejection, therefore the immunosuppresive medications might need to be adjusted. Also there could be "technical" issues with the bile ducts, or if the donor liver was not in good condition it could not be functioning great. Liver enzymes elevation after transplant is not normal, and usually requires a liver biopsy for a final diagnosis.
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Liver Transplant Done. Liver Enzyme Test Shows Elevated SGOT, SGPT. How To Reduce Levels?

Hi, Liver enzymes after a liver transplant is more complex. First of all it would be important to know if your mother was infected with Hepatitis C prior to transplant, as the virus comes back 100% of the time with a new liver, therefore it can cause liver enzyme elevation. The fact that she is 3 months post-transplant makes someone think also about organ rejection, therefore the immunosuppresive medications might need to be adjusted. Also there could be technical issues with the bile ducts, or if the donor liver was not in good condition it could not be functioning great. Liver enzymes elevation after transplant is not normal, and usually requires a liver biopsy for a final diagnosis.