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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Taking Trimethoprim During Early Pregnancy Harmful?

Hello, I am newly pregnant (my period was due 21st of may) and i took trimethroprim 200 mg unknowingly to treat a urine infection. All the research i have done suggests this increases the risk of birth defects, especially in the my 1st trimester and i now think i should get an abortion. can you help? Does this increase the risk?
Wed, 13 Apr 2016
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OBGYN,  's  Response
Hello and welcome to healthcare magic.

The exact number of tablets of trimethoprim taken has not been mentioned in the question. If it is a single dose i do not think there is much cause for concern.

In case a full course has been inadvertantly administered in the first trimester then the rate of congenital malformation is higher than normal rate as per studies.

My suggestion...regularly screen for congenital anomaly in the pregnancy scans. Usually the defects are structural and are easily detectable by ultrasonography.

Still if you think that you donot wish to take any risk at all then you may consider aborting the current pregnancy.

Please consult with gynaecologist before taking any decision.

Do write back if you have any queries.
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Is Taking Trimethoprim During Early Pregnancy Harmful?

Hello and welcome to healthcare magic. The exact number of tablets of trimethoprim taken has not been mentioned in the question. If it is a single dose i do not think there is much cause for concern. In case a full course has been inadvertantly administered in the first trimester then the rate of congenital malformation is higher than normal rate as per studies. My suggestion...regularly screen for congenital anomaly in the pregnancy scans. Usually the defects are structural and are easily detectable by ultrasonography. Still if you think that you donot wish to take any risk at all then you may consider aborting the current pregnancy. Please consult with gynaecologist before taking any decision. Do write back if you have any queries.