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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is It Safe To Take Amoxicillin While On 17.5mg Of Methotrexate?

I inject myself with 17.5 mg of methotrexate once a week for psoriatic arthritis. My doctor x-rayed and diagnosed me with pneumonia. He prescribed amoxicillin/clavulanic acid oral to start tomorrow. The drugstore information flyer says a bad interaction can occur with these two drugs. My doctor may have forgotten my rheumatologist has me on methotrexate. What should I do?
Thu, 14 Sep 2017
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Pulmonologist,  's  Response
Thanks for your question on Healthcare Magic.
I can understand your concern.
Amoxicillin plain can interact with methotrexate and so antibiotic effect is reduced.
But when amoxicillin is given in combination with clavulinic acid, it is not interacting with methotrexate and hence antibacterial effect don't hamper.
So you should continue amoxicillin plus clavulinic acid for pneumonia.
Hope I have solved your query. I will be happy to help you further. Wish you good health. Thanks.
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Is It Safe To Take Amoxicillin While On 17.5mg Of Methotrexate?

Thanks for your question on Healthcare Magic. I can understand your concern. Amoxicillin plain can interact with methotrexate and so antibiotic effect is reduced. But when amoxicillin is given in combination with clavulinic acid, it is not interacting with methotrexate and hence antibacterial effect don t hamper. So you should continue amoxicillin plus clavulinic acid for pneumonia. Hope I have solved your query. I will be happy to help you further. Wish you good health. Thanks.