Hi and thank you so much for this query I am so sorry to hear about these itches. It is safe to take this drug while on Depo provera. There is no contra-ndication having the two medications taken at the same time. I hope this addresses your query fully. Thank you so much for patronizing our services and please do feel free to ask for follow up clarifications and information if need be. I wish you the best of health. Dr. Ditah, MD.