Hi there. HUMIRA is an belongs to a group of medicines known as biological disease modifying agents. It functions by blocking the action of tumor necrosis factor, an important cytokine responsible for inflammation in rheumatoid arthiritis. I have been using HUMIRA for sometime now with my patients and I have had an excellent response with it. So with respect to its effectiveness it is a very good drug. Your doctor needs to ascertain about your hepatitis and Tuberculosis status prior to starting you on HUMIRA. The main side effects of HUMIRA are increased chances of infections, ressurgence of prior TB or flare of prior Hepatitis, allergic reactions and rarely it has been associated with lymphoma also. But these are rare side effects of HUMIRA. So based on the PRO s and CON s I would suggest you give it a try. No head on studies have been done for supplements versus drugs. But if your disease is active at present I would suggest that you do not stop your medications while trying on other supplements. I hope I have been helpful. Thank you Dr Hanif