HI Thank for asking to HCM I really appreciate your concern, injury due to rusty nail particularly in sole always turns into infection and need to be treated very well with good antibiotic and anti-inflammatory drugs, while sleeping keep the foot in elevated position local antibiotic cream wont work here I would suggest the following medicine. 1) Amoxicillin+ clavulanic acid twice a day 2) Ibuprofen 400 mg three times in day the wound should be kept clean if pus is there then this should be drained and dress, this will come around with such care, I hope this may help you bye.