Hello i have gone through query.Prolia (Denosumab) is used in treating osteoporosis (weak bones) in certain women who have gone through menopause. common side effect may include; Back pain; mild joint pain; mild muscle pain; mild skin inflammation (eg, red, dry, itchy skin); mild sore throat; pain in the arms or legs; runny nose. if the mouth symptoms symptoms like jaw swelling, pain, or numbness; drainage from the mouth or teeth; sores in the mouth is seen with unusual tiredness or weakness you sud visit a doctor immediately. in your case i don think it is a side effect of prolia bumps on the floor (bottom) of the mouth can be due to; abcess trauma some cysts torus as you have visited a dentist i wud suggest you to wait for some time if the problem persists you sud have a second opinion about it. meanwhile take the course of antibiotic maintain good oral hygiene use a suitable mouthwash. Hope this ans helps Regards Dr. Shesh