Hyper side? Are you certain you know how to read your thyroid test? A high TSH means your thyroid is not working well. A low TSH generally indicates a healthier thyroid. I must ask if you are taking your medication correctly. Do you take your thyroid replacement on an empty stomach at least 1/2 hour before a meal? Do you consume soy? Soy may interfere with thyroid functioning in some people. Are you using iodized salt or obtaining adequate iodine as that is necessary for thyroid function.Proton Pump inhibitors are not generally known to cause wt gain so I am puzzled. You cannot lose wt. by not eating much, which by the way is very subjective. What is not eating much? Obviously too much for you unless you break this plateau. Despite the asthma, I would seek to keep it under control and initiate a regular exercise program starting out slow and increasing. Exercise will help you break the plateau. Start drinking green tea as that will increase your metabolic rate. Seeing a credentialed Nutritionist and having a complete food/medical assessment performed and getting some nutrition plans might help you get on the right nutritional track along with the exercise (approved by your doc). Respectfully, Kathryn Shattler, MS,RDN