Melgain Lotion is composed of Decapeptide - Basic Fibroblast Growth Factor and is used for the re-pigmentation of the skin... Melgain Lotion is generally very well tolerated with no known major side effects though allergic reaction can occur rarely... The active ingredient in this topical lotion i.e. bFGF can help to replenish the dysfunctional melanocytes in the affected areas of skin by causing healthy melanocytes from adjacent normal skin to move into the white skin patch and also accelerates their growth... Usually applied once per day as a thin layer of it, directly onto the whitened skin... Hope this would help...thanks