I have been taking depression meds for over 10 years now, after my husband was diagnosed with stage 4 colon cancer, however, I am one of the unfortunate ones, it seems as though it takes 6-8 weeks to kick in, then it is good for 6-8 months, then I am deeply down again, doctors either change my meds or increase my dosage, however again 6-8 weeks to kick in and 6-8 months it s good, then I am down again, this has been going on now for 10 years, I have probably been on 15-18 different meds. I heard about lithium, adding it to what I am already taking BUT the side effects seem very SERIOUS~~