Get your Health question answered in 3 easy steps
A Doctor will be with you shortly
Ask a Doctor Now
133 Doctors are Online

Epileptic. On Dilantin. Having high levels of liver parameters. On good diet, exercise. Reason?

I am 48 years old, female and healthy. I am epileptic and take 200 mg of Dilantin daily. I am active - I live at an altitude 9000 ft & I run a couple miles 2-4 times a week. I work long hours (desk job). I try to eat organic whenever possible, and I eat what I believe is a well-balanced diet of fruits & veggies. And I do not drink alcohol. In the last 6 months I applied for life insurance & was turned down - they sent me the results of my blood tests - a couple of results stood out to me - Alkaline Phosphatase = 139; GGT = 343; AST 30. What little I ve read on this I understand these particular tests are for my liver function. My neurologist does not think it has anything to do w/ my Dilantin, however I ve been taking this drug since I was 15 years old and it s the only thing I can think of that would cause these wacky high numbers. I had another follow-up ALP & GGT test run just 2 days ago but have not received back the results. I ve changed my diet to include beets and a liver supplement called Livaplex, so I hope this helps. But do you have any additional thoughts? Thank you, Kim
Asked On : Mon, 11 Mar 2013
Answers:  1 Views:  57
Report Abuse
Share on Facebook
Share on Twitter
Share on Google+
Question is related to
Diseases and Conditions
Lab Tests
Medical Topics
Gastroenterologist 's  Response
Hello! Thanks for putting your query in HCM. I am a Gastroenterologist (DM).

Derranged LFT may be due to dilantin or may be due to some other causes so I will advise to see for other causes for derranged LFT and if it is not there then you may have to replace dilantin with other least hepatotoxic antiepileptic.

You should test for:
1.If you are obese or overweight you need to reduce your weight
2.Other common and treatable causes like Hepatitis B and C virus, Serum ceruloplasmin for wilson disease especially if you are young, ANA and SMA for autoimmune disease
3. Lipid profile and Ultrasound abdomen to see for liver echotexture, billiary tract

One thing is little bit confusing why you have taken dilantin for such a longer period of time (33 years!). Usually antiepileptic are given for 3 years if there is no seizure. If there are seizure intermittently on dilantin, then also it has to be replaced. So regarding this I will advise you to discuss with your treating doctor

Also upload the reports of repeat LFT which you have already done.

I hope I have answered your query and this will help you. Remain in touch and get-well soon.
Answered: Tue, 23 Jul 2013
I find this answer helpful

 1 user finds this helpful

Disclaimer: These answers are for your information only and not intended to replace your relationship with your treating physician.
This is a short, free answer. For a more detailed, immediate answer, try our premium service [Sample answer]


Loading Online Doctors....
© Ebix, Inc. All Rights Reserved.
All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. You should always speak with your doctor before you follow anything that you read on this website. Any health question asked on this site will be visible to the people who browse this site. Hence, the user assumes the responsibility not to divulge any personally identifiable information in the question. Use of this site is subject to our Terms & Conditions
Already Rated.
Your rating:

Ask a Doctor