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Dr. Andrew Rynne
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Methotrexate or Humira injections cause low testosterone level?

Hello, I am currently taking Methotrexate and Humira injections to treat Crohn s Disease. My family Physicial checked my testosterone levels recently and the level came back at 214. That is very low as I am a 31 yr old male. Can either one of these drugs be the cause of a test that low?
Fri, 4 Oct 2019
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General & Family Physician 's  Response

It is commonly seen that patients suffering from RA have low testosterone levels while Methotrexate may cause low testosterone levels in men with sleep deprivation (due to increase in IL-1β which reduces the production of Leydig cell production of testosterone as found in research studies).

cal conditions that cause low testosterone levels are thyroid issues, liver, kidney or pituitary problems, obesity or weight loss, smoking, alcohol, drug abuse or addictions if any.

Get clinically assessed get treated at the earliest. To increase testosterone levels naturally do exercises & weight lifting, take proteins, vitamin D & mineral supplements, nuts, dry fruits, minimize stress & take quality sleep.

Hope I have answered your query. Let me know if I can assist you further.

Take care

Dr Nupur K, General & Family Physician
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