Hi, Medrone (methylprednisolone) is a corticosteroid medication used to reduce inflammation in various medical conditions, including multiple sclerosis (MS). However, like all medications, it can cause side effects, and some of the common side effects of Medrone include fatigue, difficulty sleeping, and mood changes. If you are experiencing these side effects, it is important to talk to your doctor. They may recommend adjustments to your medication dosage or schedule, or prescribe medications to manage your symptoms. In general, it is important to get plenty of rest and avoid over-exertion while taking Medrone, as this can exacerbate fatigue. In terms of exercise, it is generally safe to continue with light to moderate exercise while taking Medrone, but it is important to avoid high-intensity workouts or activities that could cause injury. Your doctor can provide specific guidance on exercise based on your circumstances. It is also important to follow a healthy diet and stay hydrated while taking Medrone, as this can help to manage some of the side effects. If you have any concerns about your medication or side effects, be sure to talk to your doctor for guidance. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician