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Do Benadryl And Lisinopril Affect Kidneys?
age is 63 weight is 222pounds. Ihave the starting of copd. liver disease. and high blood pressure.Ijust had a blood test that says my gfr for kidneys is 55 and was 80 a few months back. all the other tests for the kidney was fine. ws told to drink more fluids. was wondering if benadryl woud affect the kidneys and also lasinopril thanks
Wed, 4 May 2016
Hi & Welcome to HCM.
I can understand your concern.
Yes, these medications can affect the functioning of the kidneys.
The normal for an elderly person aged 63 is over 90 ml/min/1.73m2.
The given result is suggestive of acute kidney injury which seems to have been caused by the prescribed medications.
Lisinopril (ACE inhibitor) may cause changes in afferent and efferent arteries in the kidneys due to its BP lower effect. Initially the kidneys compensate by stimulating the renin–angiotensin–aldosterone–system & anti-diuretic hormone to maintain blood pressure. However, if a patient previously had hypoperfusion (decreased blood supply to the kidneys), this compensatory mechanism may fail resulting in a decreased glomerular filtration rate.
Benadryl (Diphenhydramine) can cause post-renal obstruction (blockage of the urinary tract). Obstruction can occur from the urinary tubule to the urethra resulting in urine accumulation and ultimately increasing upstream pressure and decreasing GFR.
Such elderly patient should be carefully evaluated by a physician or nephrologist and a dosage reduction of Lisinopril or use an alternate medication would restore the normal GFR.
Hope this will help.
I can understand your concern.
Yes, these medications can affect the functioning of the kidneys.
The normal for an elderly person aged 63 is over 90 ml/min/1.73m2.
The given result is suggestive of acute kidney injury which seems to have been caused by the prescribed medications.
Lisinopril (ACE inhibitor) may cause changes in afferent and efferent arteries in the kidneys due to its BP lower effect. Initially the kidneys compensate by stimulating the renin–angiotensin–aldosterone–system & anti-diuretic hormone to maintain blood pressure. However, if a patient previously had hypoperfusion (decreased blood supply to the kidneys), this compensatory mechanism may fail resulting in a decreased glomerular filtration rate.
Benadryl (Diphenhydramine) can cause post-renal obstruction (blockage of the urinary tract). Obstruction can occur from the urinary tubule to the urethra resulting in urine accumulation and ultimately increasing upstream pressure and decreasing GFR.
Such elderly patient should be carefully evaluated by a physician or nephrologist and a dosage reduction of Lisinopril or use an alternate medication would restore the normal GFR.
Hope this will help.
I find this answer helpful
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