Thanks for the query. I understand your concern for your child. Methotrexate has not been extensively tested for causing congenital disabilities and available studies show mixed results. It is difficult to give an exact number regarding the chances of affected children but my clinical experience tells me that the risk is not very high and most of the severely affected babies abort spontaneously as nature chooses the fittest. If at all an anomaly occurs it can be detected by a good quality ultrasound examination and blood tests targeted towards detecting specific defects like the Alpha Feto protein test for nervous system abnormalities which can be timed by consulting an ObGyn specialist. Regarding Humira, this drug crosses the placenta to reach the baby mostly in the third trimester and you are still in the first trimester. Also this drug is not known to cause any fetal toxicity so you need not worry for the same. It was a pleasure reviewing your case, hope you find it useful. Have a good day and feel free to consult me whenever you need!