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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Could There Be Any Negative Reactions Between Adderal And Cymbalta?

My daughter has been taking adderal for adult ADHD (30mg twice a day) and she suffers from body pain and anxiety and depression. She was just put on Cymbalta once a day with it and I wondered if there are any negative interactions between the two drugs.
Thu, 5 Jun 2014
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Psychiatrist,  's  Response
Hi,

I can understand your concerns regarding Adderal (amphetamine) and cymbalta (duloxetine). Amphetamine and duloxetine do have interactions.

Duloxetine has the propensity to increase the likelihood of side effects of amphetamine like tremors and restlessness. There is also a risk of a very rare condition called serotonin syndrome. This condition occurs very rarely but has significant symptoms. It can lead to confusion, nausea, vomiting, palpitations, fever, sweating, tremors, and increase the risk of seizure.

Both the medications can be used together though. But in case of any of the above mentioned symptoms, please do contact your doctor without any delay.

Hope this information was helpful. Best wishes.
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Could There Be Any Negative Reactions Between Adderal And Cymbalta?

Hi, I can understand your concerns regarding Adderal (amphetamine) and cymbalta (duloxetine). Amphetamine and duloxetine do have interactions. Duloxetine has the propensity to increase the likelihood of side effects of amphetamine like tremors and restlessness. There is also a risk of a very rare condition called serotonin syndrome. This condition occurs very rarely but has significant symptoms. It can lead to confusion, nausea, vomiting, palpitations, fever, sweating, tremors, and increase the risk of seizure. Both the medications can be used together though. But in case of any of the above mentioned symptoms, please do contact your doctor without any delay. Hope this information was helpful. Best wishes.