Hello, neither glimepiride (glimy) nor metformin (glycomet) are supposed to justify the leg edema. You need assessment for its cause. Possible causes include heart failure, kidney problems (diabetic nephropathy with increased protein in the urine), vein insufficiency, other drugs etc. 168 mg/dL is very high for a fasting glucose measurement. You should consider adding another pill to your regimen or switching to insulin. You haven t provided enough details about your medical history to allow for a more detailed approach. If you d like to provide the details, I d be happy to guide you to a better sugar control. Kind Regards!