Hi Welcome to HCM, If there is a high exposure risk, yes the possibility can not be avoided. Diagnosis of Lyme disease is usually based on the recognition of a characteristic clinical picture, exposure in an endemic area, and, except in those with EM, a positive antibody response to B. burgdorferi. For serologic testing recommendtion is a two-test approach in which samples are first tested by enzyme-linked immunosorbent assay (ELISA) and those with equivocal or positive results are tested by Western blotting. Hope it s clear. Regards.