Dear Doctor I hope you will be fine. I got married in 26 Apr 2006 ( 5 years back) with my second cousin. My wife got pregnant in Jun 2008 and after getting pregnant, she has started spotting and treated in hospital with following:- IVF C Injection 5000 IU ( Total 4x , 1x per week) Duphastan Tablets (1 Tablet 2 months in First Trimster) During First pregnancy, she also took other multi-vitamins like B-Complex Syrup, Maltofer Tablets, Folic Acid, Ensure Powder and good diets with fruit and fresh juices. Our first baby (girl) was born in 8 Mar 2009 by C-Section and died after 6 days. Baby had good health 3.9 KG Weight. My wife got pregnant same year in Jul 2009 and after getting pregnant, she has again started spotting and hospitalized with same following treatment:- IVF C Injection 5000 IU ( Total 4x , 1x per week) Duphastan Tablets (1 Tablet 2 months in First Trimster) During 2nd pregnancy, she also took other multi-vitamins like B-Complex Syrup, Maltofer Tablets, Folic Acid, Ensure Powder and good diets with fruit and fresh juices. Our second baby (boy) was born in 1 Apr 2010 by C-Section and died after 5 days. Baby was properly examined by Child Specialist when he was born (good health 3.5 KG) but death occurred same as previous year. Following are the investigations by Child specialist:- “C/O Poor Feeding, Excessive Crying and Fever. Kept in NICU within four hours , he developed Cardiogenic Shocks. He had severe bradycardia and Hypotension. Complex Congenital heart Disease was suspected. However Echocardiography could not be done as that facility was available at other Hospital and child condition was not allow us to shift to other hospital from NICU. He died after 24 hours in NICU.” After these two losses, our Gynochologist recommended following tests:- a. Anti Cardiolipin Antibodies LgG - Less than 5 b. Antibody to Cytomegaloviur - 1/40 (by Complement Fixation Test) c. lgG antibody to Rubella Virus By ELISA - Positive (by ELISA method) d. CRP – C reactive protein - Less than 6 e. Toxoplasma Antibodies - Reference Ranges (Comment Titre 1/16 or less : Negative) (1/32 to 1/128 : Equivocal) ( 1/128 : Suggestive) f. Karyotype of Couples - Wife - 46, XX (Cytogenetic Studies) g. Karyotype of Couples - Husband - 46, XY (Cytogenetic Studies) My Wife have also problem with lechoria as in both pregnancies, whenever she got pregnant, water like liquid was coming from her and she still have this problem. Is lechoria can effect on developing a healthy baby? I am afraid that when she got pregnancy in near future, she may develop spotting and IVF C Injection and Duphastan Tablets will be given to her which I think adversely effect on baby health. Right now, we are try to find out problem which causes our babies death in past. Can you advise us what should we do for our future pregnancy. Following I think have problems area:- a. Lechoria b. Blood Spooting after pregnancy (1st Trimster). c. IVF-C Injections and Duphastan Tablets that effect on Baby health. e. Wife ovary or Uretus problem. Please advise us with your expert opinion. Shahid YYYY@YYYY Mob:- 0321-0000