Instaflex claims to contain glucosamine, chondroitin, MSM, tumeric, ginger, cayenne pepper, boswellia, white willow bark extract, and hyaluronan. Instaflex and other supplements are not regulated by the FDA, nor have they been thoroughly tested for safety and effectiveness. But, there is limited data on some of the ingredients of Instaflex. 1.GLUCOSAMINE-a naturally occurring chemical found in the fluid around joints. It also plays a role in building tendons, ligaments, and cartilage. Glucosamine supplements may increase the cartilage and fluid surrounding joints and help prevent their breakdown. Some research suggests that glucosamine can decrease joint pain about as much as the over-the-counter pain relievers such as acetaminophen, ibuprofen, and naproxen. Glucosamine takes about 4 weeks to achieve any benefit. Glucosamine does not relieve pain in everyone who takes it, and many people see no benefit. Glucosamine has been reported to cause side effects including nausea, heartburn, diarrhea, and constipation. 2.CHONDROITIN SULPHATE is also a chemical that is found in cartilage in the body. chondroitin has been reported to cause stomach pain, nausea, diarrhea, constipation, leg swelling, hair loss, and irregular heartbeat. 3. HYALURONIC ACID- Hyaluronan (hyaluronic acid) is a substance found in the joints. Research shows that it may help relieve joint pain by acting as a cushion and lubricant when injected into the joint. SIDE EFFECTS unknown. rest are natural ingredient so side effects will be minimal. And this will certainly no link with pregnancy of your wife. Best of luck.