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74 years. Loose stools. Diagnosed hyperplastic polyp. No relief with medication. Recommend

Hi my mother 74yrs old Female is siffering from loose stools for many months all tests done colonoscopy showed Hyperplastic polyp she is on medication but the situation continues today she was adviced to take Normaxin still no respite.she has undergone angioplasty and consuming medication for other ailments for many years
Asked On : Wed, 1 May 2013
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Oncologist, Radiation 's  Response

The most common reason in this age of loose motion, not responding to conventional medicines is paraneoplastic syndrome where VIP, vasodilators and somatostatin are secreted from various cancers, most common being neuro endocrine tumors and carcinoids arising in GI, Head pancreas, lung. These chemicals can be detected on urine examine.

Chemicals against these causative agents are available and immediately started

As for treatment is concerned in her age, immediate correction of dehydration and electrolytes should be corrected and lomotil or Imosac or lopramidi 2 tab stat followed by 8 -6 hourly should be tried until primary tumor is detected and imaging, preferably PET-CT Scan and removed.

In view of her age, if surgery is not possible, a palliative dose of Radiotherapy about 30Gy in 10 fractions in 2 weeks should be considered after pathological confirmation by 3DCRT or IMRT may wonderfully improve the symptoms.

These tumors are relatively radio and chemo resistant. In view of her ase, chemotherapy should not be considered at all.

Dr. Vinay Kumar,

Senior Consultant Oncology and Radiotherapy
Answered: Sat, 4 May 2013
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