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Is Avastin effective at treating pain in the bones while on chemotherapy?

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Posted on Tue, 22 May 2018
Question: My father is currently under going cancer treatment.
Below is a brief summary of his ailment and the treatments undergone so far:
Diagnosed with CA colon (2013) resected and followed by 12 cycles of FOLFOX.
Solitary Lung Met after 1 year. Again resected and followed by 12 cycles of FOLFIRI.
Another solitary Bone Met (8th rib left side) again removed and put on METRONOMIC chemotherapy (xeloda).
Rib met reoccured on the same location after one year, with honecombing on both lungs.
Currently taking palliative treatment TAGAFUR plus Calcium Leucovorin. Also had radiation (palliative) for the pain in the rib met twice over last 6 months.

But the Bone met is causing a lot of pain and discomfort (pain goes away only for a month after radiation) then comes back.

My question is can we do something about this bone pain? Is Avastin known to reduce the size of bone mets? or is there any other such drug?
Can we do radiation again to the same rib met? or may be attempt for more aggressive radiation.
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Answered by Dr. Deepak Sundriyal (1 hour later)
Brief Answer:
HELLO. TARGETED DRUG CAN BE ADDED

Detailed Answer:

Hello dear. I have gone through your details. So your father has still not received targeted drug like erbitux and avastin. Either of these can be added to chemotherapy for an added response. prior to that kras, nras and braf mutation test needs to be done.
Re-irradiation is not possible in the same area.
For pain relief, various drugs like non steroidal anti inflammatory drugs, opioids can be tried with good pain control.
Hope this is helpful
Feel free to ask further
Thanks and regard
Above answer was peer-reviewed by : Dr. Nagamani Ng
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Answered by
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Dr. Deepak Sundriyal

Oncologist

Practicing since :2005

Answered : 1546 Questions

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Is Avastin effective at treating pain in the bones while on chemotherapy?

Brief Answer: HELLO. TARGETED DRUG CAN BE ADDED Detailed Answer: Hello dear. I have gone through your details. So your father has still not received targeted drug like erbitux and avastin. Either of these can be added to chemotherapy for an added response. prior to that kras, nras and braf mutation test needs to be done. Re-irradiation is not possible in the same area. For pain relief, various drugs like non steroidal anti inflammatory drugs, opioids can be tried with good pain control. Hope this is helpful Feel free to ask further Thanks and regard