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Dr. Andrew Rynne

Family Physician

Exp 50 years

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What does my bone marrow biopsy/aspiration report indicate?

Answered by
Dr. Jyothi B L

Pathologist and Microbiologist

Practicing since :2003

Answered : 849 Questions

Posted on Tue, 5 Aug 2014 in Blood Disorders
Question: Hello,

Below is part of my bone marrow biopsy/aspiration report. We are still awaiting cytogenetics. The doctor is on vacation so I was wondering if my results so far are normal. Bone marrow was done because of recent low platelets. I have been on prednisone for over three years and recently stopped. Thank you.

Following processing for flow cytometry, there are 77%
myeloid/granulocytic cells, 4% monocytes, 2% nucleated red blood cells,
1% immunophenotypically unremarkable myeloblasts and 4% immature B
cells immunophenotypically consistent with hematogones. About 12%
small sized lymphoid cells are seen, which are composed of
immunophenotypically unremarkable T cells and CD56+ NK cells. A small
number of CD10- polyclonal B cells are also seen. Aberrant marker
expression is not identified.
Answered by Dr. Jyothi B L 53 minutes later
Brief Answer:
Report appears to be within normal limits.

Detailed Answer:
I am Dr. Jyothi BL and I will be answering the query.

After going through the report, I am of the opinion that the flow cytometry report is within normal limits.
The myeloid series (both mature and immature) and lymphoid series (both mature and immature) along with erythroid series is within normal limits.

If you attach the whole report of CD markers if available, I can help you better.
If you have any further queries, happy to help again.

Dr. Jyothi BL

Above answer was peer-reviewed by : Dr. Vaishalee Punj
Follow up: Dr. Jyothi B L 46 minutes later
Thank you Dr! Below is the rest. Still awaiting cytogenetics report.

The bone marrow aspirate smear slides show hemodiluted smears without
any bone marrow particles. Only very scattered myeloid and erythroid
cellular elements are seen. The aspirate smear slides are suboptimal
for calculating the percentage of blasts. The bone marrow aspirate
clot section slides show blood admixed with focal trilineage
hematopoietic bone marrow with normal myeloid to erythroid cell ratio.
Megakaryocytes are mildly increased in number with unremarkable
morphology. Definite sheets of blasts or lymphoid aggregates are not
seen. The bone marrow biopsy slides show about 1.2 cm length of bone
marrow biopsy core with severe aspiration artifact. From the intact
areas, the bone marrow cellularity is estimated as 50%. Flow
cytometric studies performed at Inova Fairfax Hospital (FL-14-428) show
no immunophenotypic abnormalities. Well-controlled immunohistochemical
stains were performed. The CD20 and CD3 stains highlight very rare B
cells and scattered T cells, respectively. CD34 and CD117 stains show
no increased number of blasts. MPO and glycophorin stains show myeloid
and erythroid cellular elements. CD61 stain shows mild to focally
moderately increased number of megakaryocytes.
Answered by Dr. Jyothi B L 2 hours later
Brief Answer:
At present, all reports are normal

Detailed Answer:
The whole report also indicates similar findings and at present, all report appears to be normal.
Presence of increase blast cells indicate cancer and there is no evidence till now and cytogenetics is not expected to show any.
As the preliminary diagnostic methods failed or were inconclusive, further study is being done.
However, i did not see a peripheral smear report and hemogram or complete blood count report. If you have it, do attach it during your next follow up.

Any further queries, happy to help again.
Dr. Jyothi BL

Above answer was peer-reviewed by : Dr. Raju A.T
Follow up: Dr. Jyothi B L 4 hours later

Isn't the last part of the report that explains smear slides are suboptimal the peripheral smear report?

They did not draw blood before the bone marrow biopsy if that is what you are referring to.

Thank you for your help.
Answered by Dr. Jyothi B L 4 hours later
Brief Answer:
Look for the report of low platelet count.

Detailed Answer:
Suboptimal smear is bone marrow aspiration smear.
The second one is correct. They would have drawn blood to make a diagnosis of low platelet count. In that report, would be the complete hemogram report/ complete blood count report.
Any further queries, happy to help again.
If you do not have any further clarifications, you can close the discussion and rate the answer.

Dr. Jyothi BL
Above answer was peer-reviewed by : Dr. Raju A.T

The User accepted the expert's answer

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