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What Does My PSA Level Indicate?
Question: I am a 59 year old male 6'5", 230 lbs, and in good health. A year ago my total testosterone level was below 300 ng/dL In early 2014, my urologist proscribed a treatment of clomid (25 mg tablet every other day). I have been t along clomid for about one year. My total testosterone XXXXXXX to 696 mg/dL. It has stayed at about that level. My Total PSA level was 1.03 on 3/15/14 and 1.56 on 7/19/14. On 1/23/15, I had a blood analysis as part of a general physical and a rectal exam. The latter was normal. All of the blood work was normal except my PSA has risen to 7.0. My doctor is referring me to a urologist. I am very concerned about the possibility of prostrate cancer. What are your thoughts about my situation? Could the continued use of clomid itself cause a PSA rise? Are there any benign reasons for this rapid rise?
Brief Answer:
Yes intake of clomiphene will increase the PSA.
Detailed Answer:
Good Day and thank you for being with Healthcare Magic!
Intake of clomiphene would definitely increase the PSA. in one study comparing testosterone injections, testosterone patches and clomiphene oral. All of the testosterone therapy had an increase in PSA but The clomiphene group had the highest increase in PSA. The average increase in PSA was only 1.0ng/mL after 3 months of therapy.
You have a very high increase in your PSA jumping from 1.56 to 7.0 ng/mL. A very high doubling time would lead to higher risk of harboring prostate cancer. I would strongly suggest seeing a Urologist and possibly doing a prostate biopsy to be sure that we are not missing out on anything. Other benign conditions that may lead to increase in PSA would be infection, prostatitis, recent ejaculation. Levels of elevations varies among patients with the same conditions so it is really hard to tell unless a prostate biopsy is done.
I hope I have succeeded in providing the information you were looking for. Please feel free to write back to me for any further clarifications at: http://www.HealthcareMagic.com/doctors/dr-manuel-c-see-iv/66014 I would gladly help you. Best wishes.
Regards, Manuel C. See IV, M.D. DPBU FPUA
Yes intake of clomiphene will increase the PSA.
Detailed Answer:
Good Day and thank you for being with Healthcare Magic!
Intake of clomiphene would definitely increase the PSA. in one study comparing testosterone injections, testosterone patches and clomiphene oral. All of the testosterone therapy had an increase in PSA but The clomiphene group had the highest increase in PSA. The average increase in PSA was only 1.0ng/mL after 3 months of therapy.
You have a very high increase in your PSA jumping from 1.56 to 7.0 ng/mL. A very high doubling time would lead to higher risk of harboring prostate cancer. I would strongly suggest seeing a Urologist and possibly doing a prostate biopsy to be sure that we are not missing out on anything. Other benign conditions that may lead to increase in PSA would be infection, prostatitis, recent ejaculation. Levels of elevations varies among patients with the same conditions so it is really hard to tell unless a prostate biopsy is done.
I hope I have succeeded in providing the information you were looking for. Please feel free to write back to me for any further clarifications at: http://www.HealthcareMagic.com/doctors/dr-manuel-c-see-iv/66014 I would gladly help you. Best wishes.
Regards, Manuel C. See IV, M.D. DPBU FPUA
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Above answer was peer-reviewed by :
Dr. Yogesh D
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