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What Do These Biopsy Results Indicate?
Question: Hello,
I recently had an endoscopy...the doctor told me he suspect Barrett's esophagus..but after the biopsy he said I did not have it because there was no intestinal metaplasia or goblet cells...it was a 1.5 centimeter segment of my esophagus....it need help understanding the biopsy results and what they mean...it says I have squamoglandular mucosa, negative for intestinal metaplasia and negative for goblet cells...what is squamoglandular mucosa? I am a 29 year old healthy and active male..does this increase my cancer risk?
I recently had an endoscopy...the doctor told me he suspect Barrett's esophagus..but after the biopsy he said I did not have it because there was no intestinal metaplasia or goblet cells...it was a 1.5 centimeter segment of my esophagus....it need help understanding the biopsy results and what they mean...it says I have squamoglandular mucosa, negative for intestinal metaplasia and negative for goblet cells...what is squamoglandular mucosa? I am a 29 year old healthy and active male..does this increase my cancer risk?
Brief Answer:
Please follow the suggetsions below....
Detailed Answer:
Hi and thank you for asking!
I read carefully all your medical data and I can say as follows:
1. You are reporting to have squamo glandular mucosa of esophagus and this is a normal finding of esophageal mucosa. There is no need to be worried.
2. The fact that you don't have intestinal metaplasia or goblet cells than Barrett's esophagus is ruled out. So this finding dose not increase cancer risk.
3. Your upper endoscopic finding may be related only with GERD and esophageal mucosa inflammation, nothing else.
Otherwise it would be great if you can upload your medical reports, so I can check them by myself.
Meantime I suggest to :
- continue using PPI's like Prilosec
- avoid alcohol, smoking
- avoid fatty and spicy foods
- use two pillows when you lay down
- eat often and small amount of meal
- increase physical activity
- avoid unnecessary stress.
Wish you all the best!
Dr.Klerida
Please follow the suggetsions below....
Detailed Answer:
Hi and thank you for asking!
I read carefully all your medical data and I can say as follows:
1. You are reporting to have squamo glandular mucosa of esophagus and this is a normal finding of esophageal mucosa. There is no need to be worried.
2. The fact that you don't have intestinal metaplasia or goblet cells than Barrett's esophagus is ruled out. So this finding dose not increase cancer risk.
3. Your upper endoscopic finding may be related only with GERD and esophageal mucosa inflammation, nothing else.
Otherwise it would be great if you can upload your medical reports, so I can check them by myself.
Meantime I suggest to :
- continue using PPI's like Prilosec
- avoid alcohol, smoking
- avoid fatty and spicy foods
- use two pillows when you lay down
- eat often and small amount of meal
- increase physical activity
- avoid unnecessary stress.
Wish you all the best!
Dr.Klerida
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Thank you for your answer...squamoglandular mucosa negative for intestinal metaplasia and negative for goblet cells is all the report says...what is squamoglandular mucosa? How is that different from a columnar lined esophagus?
Also...the doctor mentioned that the surgeon could sometimes miss intestinal metaplasia if it is not present where the biopsy took place..the report says the surgeon took a segment that measures 0.4 centimeter in its greatest dimension...the report said there was a 1.5 segment of suspected Barrett's esophagus...how likely is it that I could have Barrett's that the biopsy missed? Is the biopsy more likely to be correct because it is only a short segment of suspected Barrett's as opposed to long segment? Thank you for taking the time..I am just really worried
Also...the doctor mentioned that the surgeon could sometimes miss intestinal metaplasia if it is not present where the biopsy took place..the report says the surgeon took a segment that measures 0.4 centimeter in its greatest dimension...the report said there was a 1.5 segment of suspected Barrett's esophagus...how likely is it that I could have Barrett's that the biopsy missed? Is the biopsy more likely to be correct because it is only a short segment of suspected Barrett's as opposed to long segment? Thank you for taking the time..I am just really worried
Brief Answer:
Please follow...
Detailed Answer:
Hi back and sorry for my late.
1.Squamglandular mucosa is normal mucosa of esophagus instead columnar lined esophagus is when the normal squamous lining cells of the esophagus are replaced by columnar cells. This process is called metaplasia.
At your biopsy report there was no metaplasia.
2. In my clinical practice I take 4-5 biopsies to rule out or confirm Barrett's esophagus. Since you have a small area of suspected mucosa for Barrett's ( less than 3 cm), to my opinion it is unusually that biopsy missed it.
3. The fact that I have requested your reports is that it would be great if I read by myself endoscopy report. So, I could check by my self why your doctor has a strong suspect to Barrett's esophagus.
Otherwise, If you were my patient I would suggest repeating upper endoscopy after one year on treatment with PPI's.
Wish you all the best!
Dr.Klerida
Please follow...
Detailed Answer:
Hi back and sorry for my late.
1.Squamglandular mucosa is normal mucosa of esophagus instead columnar lined esophagus is when the normal squamous lining cells of the esophagus are replaced by columnar cells. This process is called metaplasia.
At your biopsy report there was no metaplasia.
2. In my clinical practice I take 4-5 biopsies to rule out or confirm Barrett's esophagus. Since you have a small area of suspected mucosa for Barrett's ( less than 3 cm), to my opinion it is unusually that biopsy missed it.
3. The fact that I have requested your reports is that it would be great if I read by myself endoscopy report. So, I could check by my self why your doctor has a strong suspect to Barrett's esophagus.
Otherwise, If you were my patient I would suggest repeating upper endoscopy after one year on treatment with PPI's.
Wish you all the best!
Dr.Klerida
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
I have uploaded the reports as you requested...what are your thoughts? Thank you
Brief Answer:
Please follow...
Detailed Answer:
Hi back,
I read carefully your medical reports and I can say as follows.
1. Upper endoscopy report suspect for Barrett's esophagus and your surgeon has took a lot of pieces for biopsy even in a small area like 1.5 cm.
This is the reason why I believe that your surgeon hasn't missed any thing in biopsy, especially in cases like yours, when the biopsies was taken at the larger suspected area( 0.4 cm).
2. Biopsy report has clearly ruled out metaplasia. Squamoglandular mucosa doesn't mean metaplasia but normal finding in esophageal mucosa.
Hope it was helpful to you!
Dr.Klerida
Please follow...
Detailed Answer:
Hi back,
I read carefully your medical reports and I can say as follows.
1. Upper endoscopy report suspect for Barrett's esophagus and your surgeon has took a lot of pieces for biopsy even in a small area like 1.5 cm.
This is the reason why I believe that your surgeon hasn't missed any thing in biopsy, especially in cases like yours, when the biopsies was taken at the larger suspected area( 0.4 cm).
2. Biopsy report has clearly ruled out metaplasia. Squamoglandular mucosa doesn't mean metaplasia but normal finding in esophageal mucosa.
Hope it was helpful to you!
Dr.Klerida
Note: For further follow up on digestive issues share your reports here and Click here.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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