Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties
183 Doctors Online

By proceeding, I accept the Terms and Conditions

Dr. Andrew Rynne
Dr. Andrew Rynne

Family Physician

Exp 50 years

HCM Blog Instant Access to Doctors
HCM BlogQuestions Answered
HCM Blog Satisfaction

What causes persistent sore throat with negative strep tests?

Answered by
Dr. Tushar Kanti Biswas

Internal Medicine Specialist

Practicing since :1975

Answered : 1909 Questions

Posted on Fri, 13 Mar 2015 in Ear, Nose and Throat Problems
Question: My daughter (16) has had a sore throat for 3 weeks that has been worsening. She has had 2 strep tests and 1 mono test, the rapid report states that they are both negative, we are awaiting the final results. She had mono when she was 8 years old, I personally do not think that she has this. Her tonsils are very large however the Dr's do not see anything there. When I listen to her it is evident that her throat hurts, she sounds like she has swallowed an orange. Her breath smells of infection, (no periodontal disease or gingivitis). She breathes from her mouth now and she sounds as if she has a deep sinus thing going on.
Answered by Dr. Tushar Kanti Biswas 34 minutes later
Brief Answer:
Throat infection

Detailed Answer:

Thank you for your query. I can understand your concerns.

Rapid strep tests sometimes may miss streptococcal throat infection. As her symptoms are persistent, I will advice throat swab culture which remains the golden test. Pending culture report you need to start a first line antibiotic e.g. azithromycin (standard adult dose 500 mg orally daily for a period of 3-5 days) or Linezolid empirically.

Monospot test is done to check for antibodies to the Epstein-Barr virus. The currrent symptoms may or may not be related.

You need to discuss with your doctor.


Dr. T.K. Biswas M.D. XXXXXXX

Above answer was peer-reviewed by : Dr. Prasad

The User accepted the expert's answer

Share on
Question is related to
Diseases and Conditions ,   ,  

Recent questions on  Sore throat

doctor1 MD

Hi....I m suffering from pain on one side of my neck jaw and face that aggravates when I speak...m really worried as it s been more than six months...

doctor1 MD

My 6 year old daughter is complaining of a sore throat and some body aches. The only medicine I have in the house is Nyquil and I have no funds...

doctor1 MD

I am recovering from thyroiditis, waiting for my levels to come throat is sore again and have thick catarrh stuck low in my throat.....I...

doctor1 MD

Hubby has chrone he hurt his back and cant walk so we took him to hospital when he got there he needed a blood transfusion 4 bags and also a bag of...

doctor1 MD

For the past 3 weeks I have had a very persistent sore throat which at times has made it very difficult to swallow. Lemsips and lozengers ease and...

doctor1 MD

I was treated for strep about a month ago. Still have lingering cough . Not bad, but still there. Could this be due to post nasal drip?

doctor1 MD

Temperature 103.1 Very bad sore throat Difficulty swallowing Discolored sputum Chills