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What Causes Loss Of Consciousness And Hand Tremors In A Chronic Epileptic Patient?

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Posted on Tue, 16 Feb 2016
Question: Dear Sir
I am impressed with some of the replies given by you on healthcare magic
My wife aged 44 years is chronic epileptic patient since Last 24 years, As a child she had history of ,meningitis and got cured. she has been on different medications at different points of time, but she never got seizure free for more than a month. At times she get mild fits like arm and mouth twitching with loss of consciousness for few minutes approx(4-5 mts or so ) and at times Violent falls abruptly(with thumping sound) and getting severely hurt because of these falls etc.Mostly happens suddenly without any prior signals or indication or trigger. Most of the violent and abrupt falls usually happen during the morning time ( 5 am -8am) after waking up.
Dicorate ER worked reasonably for some time but resulted in serious side effects like hand tremors and thinning down , loss of apetite etc and tapered down gradually and levipil introduced in its place 1 year back
Currently she is on following medications
1-LOBAZEM MD 10mg 1 time at bed
2-LAMITOR OD 50 mg 9AM
3-LEVIPIL 1000 mg daily twice 8am and 8 pm
4-ZEPTOL CR 300 mg daily twice 8.30 am and 8.30 pm
I am very worried and feel frightened when I look at her abrupt violent falls resulting in severe injuries, kindly advise any add on medication or changes in dosage to the existing medication and also let me know SOS medication strategy in case of mild attacks and abrupt falls to reduce the intensity or further occurance of attacks after some time in the same day.
One more observation I made is some times initially start with 1 or 2 mild attacks and after a day or two it will be followed by a major attack.
Considering her long term chronic epileptic condition , kindly advise
Regards
KRK, New XXXXXXX
doctor
Answered by Dr. Sudhir Kumar (4 hours later)
Brief Answer:
Dose adjustment is needed.

Detailed Answer:
Hi,

Thank you for posting your query.

I have noted your wife's clinical condition. It is unfortunate that her epilepsy is still uncontrolled after so many years of medications.

She is on reasonably good medications, however dose adjustments are needed.

The most important step is to gradually increase the dose of lamotrigine (LAMITOR OD) to 200 mg per day. The dose should be increased by 25 mg every two weeks and not faster than that; rapid increase in dose of lamotrigine may result in skin rash. So, it should take about two-three months to reach a dose of LAMITOR OD 100 mg two times daily.

Continue other medicines as it is, for the time being.

DICORATE ER (divalproex) usually causes weight gain. So, it is surprising that she lost weight with that.

Best wishes,

Dr Sudhir Kumar MD DM (Neurology) XXXXXXX Consultant Neurologist
Above answer was peer-reviewed by : Dr. Vaishalee Punj
doctor
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Follow up: Dr. Sudhir Kumar (13 hours later)
Dear Sir

Thanks a lot for the reply, can you suggest any medication on sos basis (with dosage n frequency for usage for a day or two) that can prevent further attacks on the same day or in short duration say day or two days interval when minor/severe attacks initiated suddenly.
doctor
Answered by Dr. Sudhir Kumar (58 minutes later)
Brief Answer:
Frisium is the best for sos use.

Detailed Answer:
Thank you for getting back.

To prevent further seizures on the same day, Frisium (CLOBAZAM) 10 mg can be used on sos basis.

Best wishes,

Dr Sudhir Kumar MD DM (Neurology)
Above answer was peer-reviewed by : Dr. Prasad
doctor
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Follow up: Dr. Sudhir Kumar (2 hours later)
Dear Sir
When sudden seizures start( either mild or severe in seizure) what is the best strategy to ward off precipitating further intense attacks in near future.
Either in terms of medication or dosage adjustments etc
doctor
Answered by Dr. Sudhir Kumar (57 minutes later)
Brief Answer:
Frisium is the best

Detailed Answer:
Thank you for getting back.

To prevent further seizures, I would start Frisium 10 mg tablets. Other option is midaspray (midazolam nasal spray).

If seizures continue despite above treatment, then, injection lorazepam may be taken at a nearby clinic.

Best wishes,

Dr Sudhir Kumar MD DM (Neurology)
Above answer was peer-reviewed by : Dr. Prasad
doctor
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Follow up: Dr. Sudhir Kumar (21 hours later)
Dear Sir

Thanks a lot for your guidance. As i mentioned earlier initially it starts with a mild episode of fit and then gradually over a period of time it builds up and precipitate into a major attack. Is it better to go for change or adjustment in the existing dosage on the same day of minor attack itself instead of waiting for major attack to precipitate and then go to the doctor for doage change to ward off further major attack. Pls advice.
Regards
doctor
Answered by Dr. Sudhir Kumar (6 hours later)
Brief Answer:
Stable dose is needed.

Detailed Answer:
Thank you for getting back.

The decision to change the dose/medication is not based on a single seizure. It is based on the total number of seizures in a month or previous three months. If there are seizures occurring on a regular basis, it would need change of dose/medication. On the other hand, an occasional minor or major seizure may not warrant any change.

Best wishes,

Dr Sudhir Kumar MD DM (Neurology)
Note: For further follow up on related General & Family Physician Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Sudhir Kumar

Neurologist

Practicing since :1994

Answered : 6232 Questions

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What Causes Loss Of Consciousness And Hand Tremors In A Chronic Epileptic Patient?

Brief Answer: Dose adjustment is needed. Detailed Answer: Hi, Thank you for posting your query. I have noted your wife's clinical condition. It is unfortunate that her epilepsy is still uncontrolled after so many years of medications. She is on reasonably good medications, however dose adjustments are needed. The most important step is to gradually increase the dose of lamotrigine (LAMITOR OD) to 200 mg per day. The dose should be increased by 25 mg every two weeks and not faster than that; rapid increase in dose of lamotrigine may result in skin rash. So, it should take about two-three months to reach a dose of LAMITOR OD 100 mg two times daily. Continue other medicines as it is, for the time being. DICORATE ER (divalproex) usually causes weight gain. So, it is surprising that she lost weight with that. Best wishes, Dr Sudhir Kumar MD DM (Neurology) XXXXXXX Consultant Neurologist