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What Causes Elevated TSH Levels In A Diabetic Patient?

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Posted on Wed, 27 May 2015
Question: My husband is a diabetic. His endocrinologist had his thyroid checked with his last lab work. His TSH is high, his T4 is low, and his T3 is normal! Any thoughts on this?

The doctor wants to check levels again in 30 days before beginning any meds.

He retired 9-30-2013 due to problems with concentration, etc. He was a minister.
doctor
Answered by Dr. Binu Parameswaran Pillai (29 minutes later)
Brief Answer:
Abnormal TFT

Detailed Answer:
Good day,
Noted your concern.
I would like to know if the T4 was total T4 or a Free t4 ( FT4) ? and How high was TSH.
T3 could be normal XXXXXXX to excess conversion of T4 to T3.

Free T4 is more important than Total T4 when we decide treatment.
Could you attach the thyroid blood work report??

Your endocrinologist has chosen to wait , probably due to inadequate clinical evidence of hypothyroidism.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Binu Parameswaran Pillai (10 hours later)
The T4 test was "Free T4" with range values of 0.59-1.17 ng/dL given. His was 0.62.

His TSH was 5.150 with range of 0.340-4.820 given.

His T3 was 125 in range of 71-180.
doctor
Answered by Dr. Binu Parameswaran Pillai (7 minutes later)
Brief Answer:
Sub clinical Hypothyroidism

Detailed Answer:
Thank you for the reply.
Now the picture is more clear. He has a mild "Sub clinical Hypothyroidism" where FT4 and Ft3 are normal and TSH alone is elevated.

You can see that FT4 is not low, it is still in normal range. Please be aware that Ft4 is expressed in ng/dl and Ft3 is expressed in pmol/L. So the Ft3 number is appearing high. I can assure that both Ft4 and Ft3 are normal.

Does he have an enlarged thyroid?? I would totally agree with your endocrinologist in waiting and repeating the test in 3 months time. There is evidence that in elderly population, a slightly high TSH is protective and treating it may be harmful. If the TSH was more that 10, we would certainly treat irrespective of Ft4 levels.

I would strongly recommend to do an "Anti TPO" blood levels along with TFT in his next blood works 3 months later.

Regards
Binu
Note: For more information on hormonal imbalance symptoms or unmanaged diabetes with other comorbid conditions, get back to us & Consult with an Endocrinologist. Click here to book an appointment.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Binu Parameswaran Pillai

Endocrinologist

Practicing since :2003

Answered : 1439 Questions

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What Causes Elevated TSH Levels In A Diabetic Patient?

Brief Answer: Abnormal TFT Detailed Answer: Good day, Noted your concern. I would like to know if the T4 was total T4 or a Free t4 ( FT4) ? and How high was TSH. T3 could be normal XXXXXXX to excess conversion of T4 to T3. Free T4 is more important than Total T4 when we decide treatment. Could you attach the thyroid blood work report?? Your endocrinologist has chosen to wait , probably due to inadequate clinical evidence of hypothyroidism.