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What Causes OCD Despite Taking Keppra?
Question: I was taking until some time ago 1000mg Keppra as mood stabilizer, Klonopin 1mg, Lexapro 2.5 mg and amisulpride (Solian) 100mg. My psychiatrist decidedf to change Keppra for Gabapentin, but this med didn't worked and suddenly an old OCD reappeared. It was under control until the change of Keppra for Gabapentin. But the most strange thing is that when my psychiatrist decided to go back to Keppra, the problem was not resolved as before, i mean, the symptom of OCD stayed. My question is: why the problem was not there at the beginning, it appeared with the change of antiepileptic (to Gabapentin) BUT it NOT disappeared going back to Keppra, while Keppra was working BEFORE the change? Is there any kind competition between meds (in the liver and kidneys) that could explain that Keppra was not able to do the same effect because it was retired for two weeks in the replacement by Gabapentin?
Thanks beforehand
Thanks beforehand
Brief Answer:
That could be due to receptor desensitization
Detailed Answer:
HI
Thanks for using healthcare magic. I, Dr Abhishek Kapoor, would help you in this query.
Keppra contains Levetiracetam and it takes time to show response. Usually medicines like antiepileptic take two weeks to show response. At first attempt, you got response with it. That could be due to medicine's anxiolytic effect, but gradually, medicine may have got tolerance. Due to tolerance, sometime, drug does not show sufficient effect. In your case, that could be the reason. Sometime, due to tolerance or receptor desensitization, medicine does not show desired effect. In that case, you have to wait or try another drug like antidepressant fluoxetine, fluvoxamine etc. Better to consult your psychiatrist for proper management.
In case, you need further help, you can ask.
Regards
Dr. Abhishek Kapoor
Psychiatrist
That could be due to receptor desensitization
Detailed Answer:
HI
Thanks for using healthcare magic. I, Dr Abhishek Kapoor, would help you in this query.
Keppra contains Levetiracetam and it takes time to show response. Usually medicines like antiepileptic take two weeks to show response. At first attempt, you got response with it. That could be due to medicine's anxiolytic effect, but gradually, medicine may have got tolerance. Due to tolerance, sometime, drug does not show sufficient effect. In your case, that could be the reason. Sometime, due to tolerance or receptor desensitization, medicine does not show desired effect. In that case, you have to wait or try another drug like antidepressant fluoxetine, fluvoxamine etc. Better to consult your psychiatrist for proper management.
In case, you need further help, you can ask.
Regards
Dr. Abhishek Kapoor
Psychiatrist
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Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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