Brief Answer: Opioids and stimulants are nullifying each other Detailed Answer: Hello there! Thank you for asking. So you have two major issues. One is pain management post surgical interventions for your trauma for which you are using Hydrocodone. the other is your ADHD for which you have been switched from one stimulant drug to another one. And the third thing is that you are considering Cymbaalta Duloxetine an SSRI for your depression issues. The rest of the miscelleneous isues like deranged sleep patterns and deranged sex life are effects of the medicines you are on. So here is what you need to do. Consult a good chronic pain management specialist for the hydrocodone replacement as they are counteracting the effect of the stimulants (whether you use Vyvanase or adderall both are stimulants with a little structural difference but both are counter acted by Hydrocodone, so in result you are neither getting pain relief from hydrocodone nor ADHD relief from stimulants) you need an alternative pain management other than opioids. Now for ADHD you need behavioural , psychosocial and cognitive therapies to help your ADHD. Avoid the diet with food colors or preservatives and all the canned foods , be natural as much as you caan they excacerbate the ADHD issues. Add free fatty acids supplements to your diet, they have been proved to be some help. And last but not the least i want you to meet your ADHD doctor and discuss the treatment possibilities and let them select what are best for you. Here are the different medications options for ADHD. Discuss them with your doctor 1-Stimulants a-Methylphenidate (Ritalin, Metadate CD, Methylin ER, Ritalin SR) b-Dexmethylphenidate (Focalin, Focalin XR) c-Magnesium pemoline (Cylert) d-Dextroamphetamine and amphetamine mixtures (Adderall) e-Dextroamphetamine (Dexedrine) f-Lisdexamfetamine (Vyvanse) 2-Psychiatry Agents a-Atomoxetine (Strattera) 3-Atypical antidepressants a-Bupropion (Wellbutrin) b-Venlafaxine (Effexor) 4-Tricyclic antidepressants a-Imipramine (Tofranil) 5-Alpha2 agonists, central-acting a-Guanfacine (Intuniv) b-Clonidine (Kapvay) i repeat, the above mentioned medications classes are to be discussed with your doctor and let them choose the ones best for you, and also the plan of different pain management as current ones are nullifying each other's effect. Good Luck with you ADHD and Pain, I hope i was of some help If you have any more queries please feel free to ask other wise kindly close the discussion and rate the answer as per your experience. take some very good care of yourself. Regards Dr. S Khan

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