Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties

132 Doctors Online
Doctor Image
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

I will be looking into your question and guiding you through the process. Please write your question below.

Trying to conceive after miscarriage. Test showed DSDNA negative. Should I visit a rheumatologist?

Answered by
Dr.
Dr. Divya Agarwal

Rheumatologist

Practicing since :1999

Answered : 564 Questions

default
Posted on Wed, 23 Jan 2013 in Lupus
Question: Hello Doctor,
I had two mis-carriages in the past i am ttc next month

I have received blood work from my general doctor & OBGYN

General Doctor did for Lupus testing twice with a gap of 8 wks XXXXXXX is -Ve but
DSDNA is equivocal/Intermediate mine is around 8 (<=4 Negative; 5 to 9 intermediate, >10 Positive)

My OBGYN did couple of other tests & told every thing looks good but have
MTHFR A1298C is Positive
I am curretly on folgard

My General doctor mentioned, since DSDNA is not Positive we can plan for kids, Do i need to be concerned or should i visit a rheumotologist?
doctor
Answered by Dr. Divya Agarwal 5 hours later
Hi,
Thanks for writing to us.
From your blood work, the tests look fine as far as lupus is concerned,
But have you been worked up for antiphospholipid syndrome as that is an important concern in pregnancy.
You need to have your anti cardiolipid antibodies , lupus anti coagulant and b2glycoprotein done.
The ds DNA does not look significant.
Continue folic acid of course because of the mutation.

Conception should not be a problem but in case any of these come positive you might need to be started on aspirin.
Let me know if you have more questions
Wishing you all the best.
Above answer was peer-reviewed by : Dr. Aparna Kohli
doctor
default
Follow up: Dr. Divya Agarwal 9 days later
Thanks for quick reply, I have just checked with my OBGYN Specialist

antiphospholipid syndrome, anti cardiolipid antibodies , lupus anti coagulant and b2glycoprotein are done & all are negative (all is good)

What does this DS DNA means, Why is it indeterminate for me? Do i need to visit a rheumotologist ? For my results do i need to be worried or take any medication ?
Can it cause miscarriage for pregnancy or any complications during pregnancy ?

My results for XXXXXXX is -Ve but
DSDNA is equivocal/Intermediate mine is around 8

I am on Folgard (because of 2 copies of A1298C Homogyzos) could this be the reason for prior miscarriages ?
doctor
Answered by Dr. Divya Agarwal 10 hours later
Hi,
It's great that the antiphospholipid is negative.

The ds DNA does not hold much value in light of a negative XXXXXXX

Ds DNA actually has to be done by a particular method called indirect immunofluorescence on crithidia and your test has not been done with that, so don't worry.

The mutation could be a cause of the problem, and you are already on folic acid for that.

So that is my assessment, you don't need a rheumatological consult.

Feel free to write in in case of any further query.

Regards,

Above answer was peer-reviewed by : Dr. Shanthi.E
doctor
premium_optimized

The User accepted the expert's answer

Share on
Question is related to
Diseases and Conditions ,  
Drug/Medication

Recent questions on  Autoimmune disease

doctor1 MD

My 80 year old father has a chronic skin condition - a rash which flares up every evening.....causing a great deal of pain. Heis being treated for eczma but we think it may be something linked to nervous system. Last week he described the pain over both knees as like being covered in bees. He has had bypass surgery so takes some medication. He is well in himself except for this rash which is causing a lot of distress. He had shingles several years ago so I thought it might be related. We are looking for a diagnosis so he can start to get better. Thankyou

doctor1 MD

Been on plaquenil 200 once a day for 3 weeks for diagnosis of mixed connective disease non lupus. Woke up with measle like rash on torso and hands. Stopped plaquenil Tuesday night. it is now Friday. Aveeno baths and calamine and Benadryl. Rash has not improved

doctor1 MD

I am 24 years old male, 192cm ,previously 100 Kg, now 92 Kg, with juvenile diabetes ,power lifting since 6 years. 6 months ago I had an attack of hypoglycemia with convulsions after which I had suffered from triceps weakness, vertical diplopia and intermittent left ptosis. MRI and EMG were normal, acetyl choline antibodies were +6. I took mestinone for 2 weeks without any improvement. Now I am on Ronicol ( vasodilator) and multivitamins.

doctor1 MD

I am 43, 5'5", 180 and have high blood pressure, high cholesterol ( which is all under control now). I have celiac sprue diease, lymphaedema in both legs and constanstally have problems with rapid heart beats even in the resting stage. I have quite abit of chest pains and do not know what is going on. Any advice on what I should do?

doctor1 MD

i have been gone through the medical healthch check-up.I need your input over the attached reports. Please answer the following of my concerns : 1. What could be the reason for TSH . 2. It is always hereditary or could be developed anytime in...

doctor1 MD

Dear Dr. Ditah, THANK YOU for asking me how I am doing, as I do have several follow questions for you Here goes: 1. I have believed for some time now that I have some form of inflammation or infection in the area of my eye cage and forehead. This...

doctor1 MD

I have low body temperature, and am concerned that my thyroid may be not working optimally. My TSH is 4.13. If I reduce the stress in my life, will my thyroid bounce back ?