Question: Hi. I was diagnosed with duodenal ulcer disease that was H.Pylori negative in1994 and treated with a proton pump inhibitor that still left me with symptoms that I was told were "functional". I also got a second opinion from another excellent gastroenterologist. I'd also had increasing fatigue for years and had been on antidepressants since 1990 that didn't seem to be of much help. I continued to get much sicker until an alternative practitioner recommended i get tested for CD. My ttg was off the charts and my biopsy showed severe villous atrophy. I looked at my biopsy report from 1994 and it described a "duodenitis" which I've read can occur with CD. I've continued to have problems with an increasingly treatment-resistant depression, anxiety and fatigue. I'd been working as a "GP Psychotherapist" part-time which was the only thing i was able to do and after a severe depressive episode last year i found i was left with cognitive deficits and personality changes that made it impossible to do my job. (I'm a 55 yo female with a partner but no kids). I am really angry and think that I should have been diagnosed with CD in 1994. Do you think that is reasonable? I feel i no longer have a reason to live and despite being on a strict GFD since 2003 the only improvements have been GI and I'm no longer as weak. Everything else is worse. Thank you for your opinion. Best, XXXXXXX (Ottawa, ON)